- Obesity and Cancer
- Obesity and Overweight
- Obesity and Overweight, Childhood — see Childhood Overweight and Obesity
- Occupational Cancer
- Occupational Cancers
- Occupational Health Statistics
- Occupational Hearing Loss — see Hearing Loss, Occupational
- Occupational Mortality Surveillance (NOMS)
- Occupational Risk Assessment
- Occupational Skin Conditions — see Skin Conditions, Occupational
- Occupational Stress — see Stress, Occupational
- Occupational Violence — see Workplace Violence
- Occupationally-Acquired Infections in Healthcare Settings
- Office Environments
- Office of Communications (OC)
- Office of Equal Employment Opportunity and Workplace Equity (OEEOWE)
- Office of Health Equity (OHE)
- Office of Policy, Performance, and Evaluation (OPPE)
- Office of Readiness and Response (ORR)
- Oil and Gas Extraction Safety and Health Program
- Older Adult Drivers
- Older Adults — see Aging
- Omsk Hemorrhagic Fever (OHF)
- Onchcerciasis — see Filarial Worms
- One Health
- Opioid Use Disorder
- Opioids
- Opisthorchis Infection — see Liver Flukes
- Oral Health
- Oral Health Data Systems
- Orf Virus Infection
- Organ Transplant Safety — see Transplant Safety
- Organization, CDC — see CDC Organization
- Orientia tsutsugamushi Infection — see Typhus Fevers
- Oropouche Virus Infection
- Oroya Fever and Veruga Peruana — see Bartonella Infection
- Osmium Tetroxide
- Osteoarthritis (OA)
- Other Spotted Fever Group Rickettsioses (SFGR)
- Otitis Media — see Ear Infection
- Outbreak and Disease Surveillance, Waterborne — see Waterborne Disease and Outbreak Surveillance
- OutbreakNet Enhanced
- Outbreaks
- Ovarian Cancer
- Overdose Prevention
- Overdose Resource Exchange (ORE)
- Overweight and Obesity — see Obesity and Overweight
- Overweight and Obesity, Childhood — see Childhood Overweight and Obesity
- Oxyuriasis — see Pinworm Infection